Cefepime maxipime side effects, dosage, interactions drugs. It is usually given every 8 or 12 hours for 7 to 10 days. You should not use cefepime if you are allergic to. Cefepime is a topic covered in the johns hopkins abx guide. The pharmacokinetics of cefepime are linear over the range of 500 mg to 2 g im and do not vary with respect to. Includes dosages for bacterial infection, urinary tract infection, pneumonia and more. We present the case of a 61yearold man who developed an immediate urticarial reaction after receiving a single dose of cefepime. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Cefepime is an antibiotic used for the treatment of both grampositive and especially gramnegative infections. Cefepime dosing in modeled critically ill patients receiving shift hemofiltration or hemodialysis renal replacement therapies k. Chromatograph the system suitability solution, and record the peak responses as directed for procedure. Maxipime cefepime dosing, indications, interactions.
Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling call your doctor at once if you have. Cefepime mylan 2 g, poudre pour solution injectable avec des aliments et des boissons sans objet. Cefepime dosing in modeled critically ill patients. Cefepime is the generic form of the brandname drug maxipime, which is used to treat bacterial infections such as urinary tract infections, pneumonia, and skin infections the prescription. Johns hopkins guide app for ios, iphone, ipad, and android included. Population pharmacokinetics of cefepime in the neonate. Cefepime injection can also be given intramuscularly into a muscle. We therefore examined the pharmacokinetics of cefepime in patients with body mass index 40 kgm 2. Maxipime cefepime hydrochloride, usp for injection fda. A 2007 metaanalysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other. Multicenter trial of singledose azithromycin vs ceftriaxone in the treatment of uncomplicated gonorrhea. Cefepime structure activity relationship of diazepam cefetamet pivoxil doses. The bayesian analysispredicted cefepime trough concentration at a dose of 50 mgkg every 12 h for infants.
Cefepime dosing in modeled critically ill patients receiving. Cefepime injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously into a vein over a period of 30 minutes. Cefepime is used to treat a wide variety of bacterial infections. Cefepime is a fourthgeneration cephalosporin antibiotic. Detailed cefepime dosage information for adults and children. Webmd provides common contraindications for cefepime injection. Mueller department of clinical pharmacy, college of pharmacy, university of michigan, ann arbor, mi cefepime is a renallyeliminated antibiotic requiring dose adjustments in patients with. Jan 18, 2012 cefepime is an antibiotic used for the treatment of both grampositive and especially gramnegative infections.
Less than 1% of the administered dose is recovered from urine as nmp, 6. Freshly constituted solutions of maxipime will range in color from colorless to amber. Official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. To view the entire topic, please sign in or purchase a subscription. Push needle into the rubber bung on a cefepime vial, inject 5 mls of water, invert vial and shake until all powder dissolves then aspirate all content. Peak serum concentrations of roughly 5065 mcgml are achieved after a 2 g im dose of cefepime to healthy adult males. The dosage of cefepime injection for hemodialysis patients is 1 g on day 1 followed by 500 mg every 24 hours for the treatment of all infections except febrile neutropenia, which is 1 g every 24 hours. Elimination of cefepime is principally via renal excretion with. Maxipime cefepime hydrochloride for injection side. Cefepime was not associated with adverse developmental outcomes in rats, mice, or rabbits when administered parenterally during period of organogenesis. Cefepime cep is approved by the food and drug adminstration fda for the treatment of febrile neutropenia, empiric therapy of uncomplicated skin and soft tissue infection ssti, complicated intra. The average plasma concentrations of cefepime observed in healthy adult male volunteers n9 at various times following single 30minute infusions iv of cefepime 500 mg, 1 g, and 2 g are summarized in table 1.
Cefepime is a cephalosporin sef a low spor in antibiotic. Diferenca entre citalopram e escitalopram o escitalopram corresponde a um dos enantiomeros do citalopram, o scitalopram dai o proprio nome escitalopram. Cefepime is metabolized to nmethylpyrrolidine nmp which is rapidly converted to the noxide nmpnoxide. Maxipime cefepime hydrochloride, usp for injection for. Maxipime cefepime hydrochloride dose, indications, adverse. Informate sobre efectos secundarios, dosis, precauciones y mas en medlineplus. Cefepime maxipime side effects, dosage, interactions. Cefepime definition of cefepime by medical dictionary. Maxipime cefepime hydrochloride for injection side effects. Oct 02, 2018 cefepime is a cephalosporin sef a low spor in antibiotic. Cefepime injection should be administered at the same time each day and following the completion of hemodialysis on hemodialysis days see table 2. Urinary recovery of unchanged cefepime accounts for approximately 85% of the administered dose. Os medicamentos podem mudar suas formulacoes, recomendacoes e alertas. Administered intravenously or intramuscularly as the hydrochloride salt.
Cefepime dosing in the morbidly obese patient population. You may receive cefepime injection in a hospital or you. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Cefepime is a fourthgeneration cephalosporin with a broad antimicrobial spectrum and good activity against both grampositive and gramnegative organisms. Find out what health conditions may be a health risk when taken with cefepime injection.
Cefepime may also be used for purposes not listed in this medication guide. Sep 07, 2018 the dosage of cefepime injection for hemodialysis patients is 1 g on day 1 followed by 500 mg every 24 hours for the treatment of all infections except febrile neutropenia, which is 1 g every 24 hours. Cefepime is 100% bioavailable after im administration, reaching peak serum concentrations at 0. This medication belongs to a class of drugs known as cephalosporin antibiotics. Cefepime concentrations in serum, dialysate, and urine were determined by liquid chromatography mass spectrometry. Pharmacokinetic parameters were calculated assuming a monoexponential model. Pharmacokinetics of intraperitoneal cefepime in automated.
Cefepime imiv indicaciones, dosificacion, presentacion. Administer the antibiotics into the dialysis fluid using aseptic technique ensuring all the. One hour after ip administration, serum cefepime levels exceeded the minimum inhibitory concentration 8 microgml for susceptible organisms. Once cefepime vial is emptied into the 10 ml syringe, replace drawingup needle with 21g needle. Nov 28, 2019 cefepime is a cephalosporin sef a low spor in antibiotic. Cefepime injection is used to treat many kinds of bacterial infections, including severe or lifethreatening forms. Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin if prosthetic material is present for culturenegative nosocomial endocarditis associated with vascular cannulae or early less than 1 year after surgery prosthetic valve endocarditis. The nebraska medical center supporting evidence for alternate cefepime dosing substitution background cefepime cep is approved by the food and drug adminstration fda for the treatment of febrile neutropenia, empiric therapy of uncomplicated skin and soft tissue infection ssti, complicated intra.